Harnessing the Body’s Natural Healing Mechanisms
At EicOsis, we are pioneering a novel class of oral treatments designed to enhance the body’s ability to combat neuroinflammation. By inhibiting soluble epoxide hydrolase (sEH), our approach supports the body’s natural protective pathways, helping to restore balance in the central nervous system. This breakthrough has the potential to provide safe and effective solutions for conditions driven by neuroinflammation, including neurodegenerative diseases such as Parkinson’s and Alzheimer’s.
By targeting the root causes rather than just symptoms, our treatments offer a new way to promote long-term neurological health—without the risks associated with traditional approaches.
EicOsis Human Health
EicOsis is developing a new class of oral drugs for human pain and inflammatory conditions. EC5026, our first candidate drug, is currently undergoing Phase 1 human clinical trials. Learn more about EC5026 and our pipeline.
Evidence for Efficacy in Pain and Inflammation
In addition to showing efficacy in rodent models, sEH inhibitors relieve naturally occurring pain and inflammation in cats, dogs, and horses, supporting the translation of efficacy to humans.
Research & Publications
The scientific developments behind sEH inhibitors are the result of more than 30 years of research. Access our scientific publications and learn more about the effects of sEH inhibition for the treatment of pain.
A New Target for Pain Relief and Inflammation: the soluble Epoxide Hydrolase Enzyme (sEH)
The soluble Epoxide Hydrolase (sEH) enzyme regulates the activity of powerful anti-inflammatory fatty acids called Epoxy-fatty acids (EpFA) that are present in all cells in humans and animals. EpFAs have analgesic and anti-inflammatory properties, but are short-lived molecules that are normally eliminated within seconds. By inhibiting sEH, EpFA levels can be increased and maintained at high anti-inflammatory and analgesic levels for 24 hours or longer. Learn more about the science behind sEH inhibition.
Inhibiting sEH Relieves Pain and Inflammation Effectively
sEH inhibitors treat pain and inflammation by increasing the body’s natural anti-inflammatory mediators without severe adverse side-effects common to currently available analgesics and anti-inflammatories. sEH inhibitors are designed for once daily oral dosing.
